| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Mario Alberto Accardi | President Orexin Program | 2025-12-09 | 2,568 | $29.21 | $75.01kSell |
| Mario Alberto Accardi | President Orexin Program | 2025-12-09 | 7,432 | $28.70 | $213.28kSell |
| Mario Alberto Accardi | President Orexin Program | 2025-12-08 | 5,000 | $9.53 | $47.65kBuy |
| Mario Alberto Accardi | President Orexin Program | 2025-12-08 | 10,000 | $30.00 | $300.00kSell |
| Iqbal J. Hussain | General Counsel | 2025-11-17 | 6,000 | $5.84 | $35.04kBuy |
| Tia L. Bush | Chief Technology Quality Ofc | 2025-11-17 | 40,000 | $9.42 | $376.80kBuy |
| Tia L. Bush | Chief Technology Quality Ofc | 2025-11-17 | 40,000 | $28.00 | $1.12MSell |
| Iqbal J. Hussain | General Counsel | 2025-11-17 | 6,000 | $27.64 | $165.83kSell |
| Tia L. Bush | Chief Technology Quality Ofc | 2025-11-12 | 40,000 | $26.00 | $1.04MSell |
| Tia L. Bush | Chief Technology Quality Ofc | 2025-11-12 | 40,000 | $9.42 | $376.80kBuy |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Medicxi Ventures Management Jersey Ltd | 14.85% | 19,963,157 | $529.22M | Institution |
| Avoro Capital Advisors LLC | 8.04% | 10,808,080 | $286.52M | Institution |
| Adage Capital Partners GP LLC | 7.46% | 10,035,000 | $266.03M | Institution |
| Index Venture Life Associates VI Ltd | 7.41% | 9,961,789 | $264.09M | Institution |
| General Atlantic LP | 7.20% | 9,681,818 | $256.66M | Institution |
| Gap Bermuda Ltd | 7.20% | 9,681,818 | $256.66M | Insider |
| Fmr LLC | 4.67% | 6,277,243 | $166.41M | Institution |
| Janus Henderson Group PLC | 4.02% | 5,408,199 | $143.37M | Institution |
| Price T Rowe Associates Inc | 3.57% | 4,804,056 | $127.36M | Institution |
| Farallon Capital Management LLC | 3.22% | 4,331,318 | $114.82M | Institution |